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骨关节炎
Introduction

Osteoarthritis (OA), known as degenerative joint disease, involves both articular cartilage and subchondral bone. The progression of the diseased joint includes articular cartilage fibrillation, fissure and partial erosion, full thickness loss of articular cartilage and ends with bone exposed, and sclerosis of subchondral bone. Symptoms include joint pain, swelling and reduced motion in angle and extent. It can occur in any joint, but usually it affects hands, knees, hips or spine. A variety of causes – hereditary, developmental, metabolic, and mechanical – may initiate processes leading to loss of cartilage. OA is the most common form of arthritis, and the leading cause of chronic disability. It affects about 40 million people in the United States.

Current Treatment

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Cartilage has limited ability to repair itself because it doesn’t have a blood supply. Medications can help control the pain of OA but nothing can stop the disease process, nor is there an effective way to repair damage that has occurred. In the past decades different surgeries and therapeutic regimens such as autologous chondrocyte implantation (ACI) have been used in clinic. The reparative tissue produced after most cartilage repair techniques can appear normal grossly and even under light microscopy, but cannot with stand the demands required of an articular surface and quickly degenerate (Dr. Buckwalter). If pain becomes debilitating, joint replacement surgery may be used to improve the quality of life. Therefore, osteoarthritis treatment/cartilage repairing is still a big challenge.

Osteoarthritis Animal Model Available at PharmaLegacy

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EPIC-uCT

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Mean Histopathology Score of Rat OA Models

Total cartilage score was based on the sum of following parameters assessed: nature of predominant tissue, articular cartilage surface regularity and integrity, chondrocyte clustering, and articular cartilage degen- erative changes at the medial tibial condyle plateau (mean +/- SD).

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Histopathology Evaluation of Lewis Rats after MTT / ACLT

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The contralateral (left) femoral condyles have no remarkable gross changes. The sham surgery introduced mild articular surface changes with spotty discoloration by Indian ink staining. The articular surfaces at the peripheral of the media condyle and the patella groove showed obvious discoloration indicated by the staining of Indian ink. The histopathology evaluation showed clear difference by clustering chondrocytes in the one from ACLT rabbit (H & E, 20X)




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