As an integrated service to our recognized capabilities and expertise in the in vivo pharmacology, Pharmalegacy offers a full span histology, cytology and histopathology services to provide an advanced support for drug discovery in the areas of toxicology, oncology, immuno-oncology, disease of inflammation, metabolic, cardiovascular and neurodegeneration. We routinely perform tissue/cell processing, embedding, sectioning, special histology staining, immuno-histo and –cytochemistry staining as well as in situ hybridization with our cutting-age technology. Our qualified and experienced pathology team member works closely with our clients to assure the highest quality in a timely manner.
· Small and large animal necropsy
· High resolution gross necropsy photography
· In-situ perfusion fixation
· Ex-vivo organ perfusion fixation
· Tissue micro-dissection
· H&E staining
· Special staining: Masson trichrome, Sirius red, Oil red O, PAS, Silver and others upon request
· Immunohistochemical staining (IHC)
· Immunofluorescent staining (IF)
· Immunocytochemical staining (ICC)
· In situ hybridization (ISH)
· Fluorescent in situ hybridization (FISH)
· Biomarker screen, location, density on cell lines, tissue microarray, cell line microarray and ex-vivo tissue culture
· Non-GLP toxic pathology including gross pathology and histopathology reading, analysis, evaluation, review and report
· Biomarker localization, screening via IHC, FISH, ISH on TMA, CMA, human tissue bank, animal tissue bank as well as NHP tissue bank
· Gross necropsy photography station
· Light microscopes with digital photography
· Organ perfusion tanks
· Tissue processor
· Paraffin microtomes
· Cryostat
· Tissue slicer
· Microscopes with digital photography
· -80 C degree tissue sample storage
· Liquid nitrogen tissue sample storage
· Regular paraffin embedded block sample storage
· Biosafety hood