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软组织病理学服务

As an integrated service to our recognized capabilities and expertise in the in vivo pharmacology, Pharmalegacy offers a full span histology, cytology and histopathology services to provide an advanced support for drug discovery in the areas of toxicology, oncology, immuno-oncology, disease of inflammation, metabolic, cardiovascular and neurodegeneration. We routinely perform tissue/cell processing, embedding, sectioning, special histology staining, immuno-histo and –cytochemistry staining as well as in situ hybridization with our cutting-age technology. Our qualified and experienced pathology team member works closely with our clients to assure the highest quality in a timely manner.

Overview

·         Small and large animal necropsy

·         High resolution gross necropsy photography

·         In-situ perfusion fixation

·         Ex-vivo organ perfusion fixation

·         Tissue micro-dissection

·         H&E staining

·         Special staining: Masson trichrome,   Sirius red, Oil red O, PAS, Silver and others upon request

·         Immunohistochemical staining (IHC)

·         Immunofluorescent staining (IF)

·         Immunocytochemical staining (ICC)

·         In situ hybridization (ISH)

·         Fluorescent in situ hybridization (FISH)

Anatomical Pathology

·         Biomarker screen, location, density on cell lines, tissue microarray, cell line microarray and ex-vivo tissue culture

·         Non-GLP toxic pathology including gross pathology and histopathology reading, analysis, evaluation, review and report

·         Biomarker localization, screening via IHC, FISH, ISH on TMA, CMA, human tissue bank, animal tissue bank as well as NHP tissue bank

Facility

·         Gross necropsy photography station

·         Light microscopes with digital photography

·         Organ perfusion tanks

·         Tissue processor              

·         Paraffin microtomes

·         Cryostat

·         Tissue slicer

·         Microscopes with digital photography

·         -80 C degree tissue sample storage

·         Liquid nitrogen tissue sample storage

·         Regular paraffin embedded block sample storage

·         Biosafety hood


Liver inflammatory diseases


Lung Pathology (H & E staining)

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IHC staining after lung tumor tissue culture

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